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COMT Gene Mutation Test: Stress, Hormones & the Nervous System

Some people thrive under pressure. Others feel overwhelmed, anxious, or “wired-but-tired.” This difference is often genetic. Often called the Warrior vs. Worrier Gene, the COMT Gene mutation test helps explain how your body clears stress chemicals and estrogen. This offers powerful insight into anxiety, sleep, focus, and hormone balance.

What Does the COMT Gene Do?

The COMT gene (Catechol-O-Methyltransferase) helps break down specific chemicals in your body. Think of it as your body’s “cleanup crew” for stimulation. It regulates:

COMT acts like the body’s “off switch” for stimulation. The speed at which that switch operates affects your nervous system, mood, and hormone balance.

COMT gene test

COMT Variants Explained: Warrior vs. Worrier

dnaPower tests key COMT variants, which influence how quickly stimulation is cleared from your system.

Slow COMT (“Worrier” Pattern)

Fast COMT (“Warrior” Pattern)

Neither type is “good” or “bad”; they simply require different support strategies.

COMT Affects Stress, Energy, Hormones & Sleep

The COMT gene is often described as a “mood gene,” but its influence is much broader.

Stress and Burnout

Individuals with slower COMT activity often feel overstimulated in busy environments. They are also more prone to burnout after prolonged periods of stress because their body takes longer to return to baseline.

Hormone Balance

COMT plays a vital role in estrogen clearance. When estrogen metabolites linger longer, symptoms can feel amplified—even when standard hormone blood tests look normal. This is often linked to:

Sleep Disruption

For "Worriers" (Slow COMT), shutting the brain off at night can be challenging. Racing thoughts and physical tension often prevent deep sleep.

How to Get an AHCY Gene Test
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COMT, Caffeine & Methylated Supplements

The text discusses how Slow COMT types react to methylated B-vitamins. This explains why the same coffee or supplement can feel helpful for one person and terrible for another. It’s not about willpower, it’s about how your nervous system is wired

How to Test for the COMT Gene

You do not need a referral to access this information. We have made the process simple and accessible.

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What You Can Do With Your Results

Knowing your COMT type isn’t just interesting trivia; it helps you personalize your daily life. Your report will guide you on:

Supplement Choices: Which forms of B-vitamins your brain prefers?
Diet Habits: How to manage caffeine and protein intake.
Exercise Style: Whether you need calming yoga or high-intensity training.
Lifestyle: How to pace your stress, sleep routines, and workload balance.

All these insights are included in our comprehensive totalPower test, with simple explanations and steps you can take immediately.

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Understand Your Warrior or Worrier Blueprint

If anxiety, sleep disruption, burnout, or hormone symptoms haven’t improved with generic advice, your COMT gene may be the missing piece of insight.

Learn whether your body is wired more like a Warrior or a Worrier, so you can support your stress response, energy, and hormones the right way.

Frequently Asked Questions

Some questions you may have about genetic testing and how it can transform your health jouney

Can I test for COMT at a walk-in clinic?

Generally, no. Most standard clinics do not offer preventative genetic testing for COMT. A specialized private test is usually required.

Does COMT affect sleep?

Yes. If you have a Slow COMT mutation, you may struggle to fall asleep because your body hasn’t cleared the day’s adrenaline or dopamine by bedtime.

How long do results take?

Once our lab receives your sample, results are typically ready within 3-4 weeks.

Do I need a doctor's referral?

No, you do not need a referral to order a test from dnaPower.

Is this the same as 23andMe?

While both analyze DNA, dnaPower focuses specifically on health optimization. We provide detailed lifestyle, diet, and fitness recommendations based on your results, with a focus on Canadian health standards and support.

Ready to find your balance? Fill out the form and connect with our team.