TCN2 Gene Test: Is Vitamin B12 Reaching Your Cells?
Some people take Vitamin B12 for years but still feel tired. Even if blood tests look normal, you might still have brain fog or nerve pain. Often, the missing piece is your DNA. At dnaPower, our TCN2 gene test helps explain how Vitamin B12 is delivered into your cells. This is where the vitamin actually does its work to give you energy.
What Does the TCN2 Gene Do?
The TCN2 gene (Transcobalamin II) provides instructions for making the protein that transports vitamin B12 into your cells.
Here’s the simple version:
- You consume or absorb B12
- B12 enters the bloodstream
- TCN2 carries B12 into cells
If this transport step is inefficient, B12 may circulate in the blood but never fully reach the tissues that need it.
Understanding Your TCN2 Results
dnaPower tests key TCN2 variations that influence cellular B12 delivery.
Efficient TCN2 Transport
- B12 moves smoothly into your cells.
- Supplements usually work exactly as expected.
- Your energy and focus respond well to vitamins.
Reduced TCN2 Transport
- B12 delivery into your cells is limited.
- Blood levels look "normal" even when you feel tired.
- You may need higher doses or different types of B12.
TCN2 Affects More Than Just Energy
Because B12 is used by almost every part of your body, inefficient transport can cause several issues:
- Brain and Nerve Health: B12 helps protect your nerves and makes brain chemicals. Poor delivery can lead to tingling, numbness, or trouble concentrating.
- Red Blood Cells: Your body needs B12 to make healthy blood. If your cells can’t get the B12 they need, you will feel constantly worn out.
- Methylation Support: This is your body's "repair system." If B12 can’t enter your cells, this whole system slows down.
- MTR & MTRR – Recycle Vitamin B12.
This is why we test TCN2 as part of a full methylation genetics panel. We don’t just look at how much B12 you take; we look at where it goes.
Why TCN2 is Important
“Normal” Blood B12, Ongoing Symptoms
TCN2 helps explain why many Canadians are told their B12 is fine, yet still feel unwell.
Aging & Absorption Changes
As we age, B12 handling becomes less efficient. Reduced cellular transport can amplify age-related fatigue or cognitive symptoms.
Plant-Based Diets
With more Canadians eating vegetarian or vegan diets, ensuring B12 actually reaches cells is critical, not just consuming it.
TCN2 and Supplements
If TCN2 transport is reduced, simply increasing B12 intake may not solve the problem.
- Why standard B12 pills haven't helped you feel better.
- Why certain forms of B12 (like sprays or drops) might work better.
- Why the way you take your vitamins matters as much as the dose.
How to Test for TCN2 at dnaPower
Simple at-home cheek swab.
No doctor referral or needles required.
Safe, easy, and done in less than a minute.
Results explained in easy, everyday language.
What You Can Do With Your Results
Knowing your TCN2 status helps you pick the right vitamin dose and form. It also helps you plan for better nerve and brain health. All these insights are part of your Total Health Blueprint, which is tailored to your lifestyles.
Stop Waiting for Your Vitamins to Work
If B12 vitamins have not given you the energy you expected, the issue might not be the supplement. It is likely a delivery problem deep inside your DNA. By doing your TCN2 gene testing with dnaPower, you can finally clear the path for B12 to enter your cells. Take control of your health and start feeling the real benefits of your nutrition today.