Explore the genes we test

Genes

Methylation Genes & Variants

Explore genes and genetic variants involved in methylation, nutrient metabolism, neurotransmitter activity, and cellular function. Select a gene below to learn what it does and how specific variations may influence your wellness.

AHCY

Adenosylhomocysteinase

Breaks down SAH to prevent inhibition of methylation

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COMT

Catechol-O-Methyltransferase

Breaks down dopamine, estrogen, and stress hormones using methyl groups (SAMe)

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FUT2

Fucosyltransferase 2

Influences B12 absorption and gut microbiome (secretor status)

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MTHFD1

Methylenetetrahydrofolate Dehydrogenase 1

Balances folate forms; produces methyl donors for DNA synthesis

MTHFR (A1298C)

Methylenetetrahydrofolate Reductase

Supports folate metabolism and BH4 production

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MTHFR (C677T)

Methylenetetrahydrofolate Reductase

Converts folate into active 5-MTHF for methylation

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MTR

Methionine Synthase

Converts homocysteine to methionine using vitamin B12

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MTRR

Methionine Synthase Reductase

Regenerates MTR enzyme activity to maintain methylation

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SHMT1

Serine Hydroxymethyltransferase 1

Converts serine to glycine; supports folate and methyl cycles

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TCN1

Transcobalamin I

Binds and stores vitamin B12 in the bloodstream

TCN2

Transcobalamin II

Transports active vitamin B12 into cells

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VDR

Vitamin D Receptor

Regulates gene expression; affects methylation via immune and B12 pathways

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